Antioxidant and Hepatoprotective Effects of Virgin Coconut Oil at Maximum Physical Activity

F A Sinaga; U Harahap; J Silalahi; Herbert Sipahutar

doi:10.32698/GCS-PSSHERS367

Antioxidant and Hepatoprotective Effects of Virgin Coconut Oil at Maximum Physical Activity

F A Sinaga^(1*), U Harahap⁽²⁾, J Silalahi⁽³⁾, Herbert Sipahutar⁽⁴⁾

(1) Department of Pharmaceutical Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
(2) Department of, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan, Medan, Indonesia
(3) Department of, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan, Medan, Indonesia
(4) Department of, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan, Medan, Indonesia
(*) Corresponding Author

Abstract

Objectives: The purpose of this study was to determine the protective effects of virgin coconut oil (VCO) treatment on hepatic oxidative stress and antioxidant defenses after maximum physical activity. Methods: This study used 24 healthy male ratss. The rats were divided into four groups randomly consisted of six rats in each group. The control group (P0) was given 2 mL water, the treatment groups (VCO-1, VCO-2, and VCO-4) were given VCO 1 mL/200gBW, 2 mL/200gBW and 4 ml/200gBW, respectively, per day using gavage spuit. The rats were trained to swim for a month, 30 min/day in the 1st week, 35 min/day in the 2nd week, 40 min/day in the 3rd week, and 45 min/day in the 4th week. After 28 days, the rats were forced to perform maximal activity by putting the rats in water with no exit. Blood samples were collected immediately after the maximum physical activity, and then all rats were killed and liver tissues were collected. The malondialdehyde; glutation peroxidase;serum glutamic oxaloacetic transaminaseand serum glutamic pyruvat transaminase level was then measured.Results: Virgin coconut oil increased swimming time to exhaustion, levels of glutathione peroxidase in liver, which were accompanied by corresponding decreases in the malondialdehyde (MDA), alanine transaminase (ALT) and aspartate transaminase (AST) content. Conclusion: The results from this study indicate that virgin coconut oil is effective in the prevention of oxidative stress ollowing maximum physical activity.

Keywords

Antioxidant, hepatoprotective effects, virgin coconut oil

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Proceeding:

Progress in Social Science, Humanities and Education Research Symposium

Publisher:

Redwhite Press

ISSN (Print):

2685-5984

ISSN (Electronic):

2685-5933

Published:

2020