4C skills are very much needed in the 21st century and the era of the industrial revolution 4.0. The 21st century is marked by the era of the industrial revolution 4.0 as the century of openness or the century of globalization. The demands of the times require students to have soft and hard skills. Mastery of hard skills and soft skillscan be realized through the integration of entrepreneurial character and science process skills (KPS) in learning. Entrepreneurial character is the character of an entrepreneur who is implemented in the entrepreneurial process. Meanwhile, science process skills are intellectual skills to acquire, develop and apply scientific concepts, principles, laws and theories, both in the form of mental skills, physical skills and social skills. Efforts to improve the soft skills and hard skills of students can be done through various methods, one of which is through Problem Based Learning (PBL). Through the PBL model, students are guided to construct their own knowledge so that learning becomes more meaningful. Teachers are expected to be able to train and integrate entrepreneurial character and science process skills. Bioentrepreneurship is a contextual biology learning approach that links the material being studied with objects or natural phenomena that exist around the lives of students. Thus, in addition to obtaining subject matter, students also have the opportunity to learn the process of processing a material into a product that is useful, has economic value and fosters interest in entrepreneurship. Through the integration of Problem Based Learning based on Bioentrepreneurship, it is hoped that it can improve the entrepreneurial character and science process skills. So as to encourage the growth of new innovators and entrepreneurs to improve student learning outcomes and science process skills.
PBL, Bioentrepreneurship, Entrepreneurship Character, KPS